Factors Influencing Binder Efficiency

The function of binders in a tablet formulation is to impart strength and to reduce the friability of granules and tablets. Several factors influence the effectiveness of a binder in a formulation. Some of these factors are related to the drug and other excipients in the formulation and others are related to the binder and solvent system used. Storage conditions as well as granulation process parameters can also significantly affect the binder efficiency. 

PVP-based granulation of detergent-cleaned hydrophilic glass beads produced larger granules with more crushing resistance and lower friability than those of dimethylsilane surface treated hydrophobic glass beads (35). The results can be attributed to the better adhesion of PVP to hydrophilic surfaces. 

HPC was reported not to have a glass transition temperature, but rather melt at a temperature of 190 195°C (46). When compared to PVP, tablets prepared using HPC maintained its dissolution profile after storage for 24 weeks under different moisture/temperature conditions while those prepared using PVP showed a reduction in pyrydazine release when stored at 40°C/75% relative humidity (46). 

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