Factors Governing Drug-Design

A few cardinal factors governing the effieacy towards the evaluation of drug design inelude a) The smaller the expenditure of human and material resourees involved to evolve a new drug of a particular value, the more viable is the design of the programme. 

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Discuss the various factors governing drug-design". 

The concept of structural similarity to the transition state has found wide application in drug design over the years. The multitude of enzyme-inhibitor interactions are governed by steric as well as electronic factors. In theory, compounds that closely resemble the transition state structure should give high binding affinity towards the target enzyme. 

The key to any analysis of molecular diversity or library design is the descriptors used. From the discussion above, it is clear that the descriptors must in some way represent, or be correlated with, the important factors governing pharmaceutical efficacy, such as receptor binding or drug transport. The descriptors to be chosen will depend on several factors, such as the number of... 

Absorption, in general, is treated as a physicochemical transport process based on computations of logP (the octanol/water partition coefficient) and solubility governed by factors such as polar surface area on the molecule. It is conceivable that SNPs in drug transporter genes will affect the pharmacokinetic properties of compounds and, therefore, these may have to be taken into consideration in the design process. 

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