3-F-BPAP

The concurrent administration of 1 mg/kg 3-F-BPAP with 0.1 mg/kg (-)-BPAP significantly inhibited the enhancer effect of (-)-BPAP, but 1 mg/kg 3-F-BPAP did not influence the enhancer effect of 1 mg/kg (-)-BPAP (Fig. 2 in Knoll et al. 2002a). This is a clear indication that the compounds bind to the same receptor, to which (-)-BPAP has a much higher affinity than 3-F-BPAP. 

Fig. 3.7. Significant enhancement of norepinephrine release from the locus coeruleus of rats isolated 30 min after the subcutaneous administration of a single dose of (-)-BPAP. The amount of norepinephrine released from the tissue within 20 min following the administration of different doses of (-)-BPAP was measured according to Knoll and Miklya (1995). Horizontal lines to the right of the graph bars show SEM. Paired Student s f-test. P < 0.05, P < 0.01, P < 0.001...

Fig. 3.12. A Protective effect of (-)-BPAP in the high micromolar concentration range, with a peak effect at 10 6M concentration, against serum-free condition induced cell death in low-cell-density culture of the cerebral cortex from E17 rats. B Lack of a protective effect of (-)-BPAP under the same conditions in the low nanomolar concentration range. Experiments were carried out in triplicate. Data are the mean SEM from six independent experiments. The data were analyzed using Student s f-test after multiple comparisons of ANOVA. P value was < 0.05 compared with the results in the vehicle-treated culture. See Hamabe et al. (2000) for methodology...

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