Extrusion/spheronisation

Battaille, B. Rahman, L. Jacob, M. Etude Des Parametres de Eormulation Sur Les Characteristiques Physico-Techniques de Granules de Theophylline Obtenus Par Extrusion-Spheronisation. Pharma. Acta Helv. 1991, 66 (8), 223-236. 

Edimo A, Leterme P, Denis J, et al. Capacity of lipophilic auxiliary substances to give spheres by extrusion-spheronisation. Drug Dev Ind Pharm 1993 19 827-842. 

Povidone can be used in all the current wet granulation techniques, including fluidized bed granulation [82,156, 425] and extrusion-spheronisation [157,... 

One specialised method of particle agglomeration is extrusion and spheronisation, to produce spherical or near-spherical particles. Such particles are suitable for coating with release modifying coats to produce controlled release formulations. The particles are usually filled into hard gelatin capsules for administration to patients. The process of extrusion/spheronisation is depicted in Figure 11.22. 

Vervaet C, Remon JP. Bioavailability of hydrochlorothiazide from pellets, made by extrusion/spheronisation, containing polyethylene glycol 400 as a dissolution enhancer. Pharm Res 1997 14(11) 1644-1646. 

Tho I, Sande SA, Kleinebudde P. Gross-linking of amidated low-methoxylated pectin with calcium during extrusion/spheronisation effect on particle size and shape. Chem Eng Sci. 60 (14) 3899-3907, 2005. 

Bornhoft M, Thommes M, Kleinebudde P. Prehminary assessment of carrageenan as excipient for extrusion/spheronisation. Eur J Pharm Biopharm. 59 (1) 127-131, 2005. 

Thommes M, Kleinebudde P. Use of kappa-carrageenan as alternative pelletisation aid to microcrystalline cellulose in extrusion/spheronisation. 1. Influence of type and fraction of filler. Eur J Pharm Biopharm. 63 (1) 59-67,2006. 

Santos H, Veiga F, Pina M, Podczeck F, Sousa J. Physical properties of chitosan pellets produced by extrusion-spheronisation Influence of formulation variables. Int J Pharm. 246 (1-2) 153-169, 2002. 

Neau SH, Chow MY, Durrani MJ. Fabrication and characterization of extruded and spheronised beads containing Carbapol 974, NF resin. Int J Pharm 1996 131 47-55. Goskonda SR. Hillman GA, Upadrashta SM. Development of matrix controlled release beads by extrusion-spheronization technology using statistical design. Drug Dev Ind Phaim 1994 20 279-92. 

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