Extravascular administration plasma concentration versus time plot

For example, in Eq. 11.12 (for intravenous bolus), (Cp)o represents the intercept of the plasma concentration versus time profile following the administration of a single dose of a drug. In Eq. 12.13 (for extravascularly administered dose), we can obtain the intercept value from the plasma concentration versus time plot. In both Eqs 11.12 and 12.13, the denominator term is identical (i.e. 1 - For an intravenous bolus, maximum or peak plasma concentration occurs at time 0 and, for an extravascular route, maximum concentration will occur at peak time (Fig. 12.3). 

Thus after 6 hours the semilog plot of Cp versus time shown in Fig. 10 becomes a straight line and kei can be determined from the slope. Therefore, the overall elimination rate constant for a drug may be accurately determined from the tail of a semilog plot of plasma concentration versus time following extravascular administration if ka is at least five times larger than kei. 

Figure 1.1 Atypical plot (rectilinear paper) of plasma concentration versus time following the administration of a drug by an extravascular route. MTC, minimum toxic concentration MEC, minimum effective concentration.

Figure 1.10 A typical semilogarithmic plot of plasma concentration (Cp) versus time following the extravascular administration of a dose of a drug that is rapidly distributed in the body.

Figure 4.8 A semilogarithmic plot of plasma or serum concentration (Cp) versus time following the administration of an identical dose of drug, by an extravascular route, to two subjects with different degree of renal insufficiency.

Figure 7.7 A typical plot of plasma concentration (Cp) versus time data following administration of a drug by an extravascular route, showing components of total area under the plasma concentration-time curve (ADC).

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See also in sourсe #XX -- [ ]

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