Extravasation injury prevention

Prevent ileus treat constipation aggressively doses range from 1-1.4 mg/m (max) doses are traditionally capped at 2 mg to minimize neurotoxicity, but capping is controversial Reduce dose by 50% for total bilirubin 1.5-3 mg/dL by 75% for total bilirubin >3 mg/dL treat extravasation injury with warm soaks, and injection of hyaluronidase LETHAL if administered intrathecally ... 

BerteUi G, Gozza A, Forno GB, Vidili MG, Silvestro S, Venturini M, Del Mastro L, Garrone O, Rosso R, Dini D. Topical dimethylsulfoxide for the prevention of soft tissue injury after extravasation of vesicant cytotoxic drugs a prospective clinical study. J Chn Oncol 1995 13(ll) 2851-5. 

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