Extracellular matrix mimicry

Extracellular matrix mimicry support of cells Native tissues are composed of extracellular matrix (ECM) that supports cells by providing structural and biochemical conditions for cell attachment, proliferation, migration, and differentiation. ECM is a noncellular component composed of collagen and elastin fiber-like. Using fibrous discontinuous stmcture helps to mimic ECM in tissue substimte designs. 

Extracellular matrix mimicry stress—strain behavior and compliance Rather than focusing on texture, one other approach arms to have similar mechanical properties to those of ECM and seems to be crucial in the cell differentiation process, especially since tissues are composed of smooth muscle cells that contract or relax depending on chemical stimuli. It has been observed that loose of vascular tissue contractility leads first to dilated vessels wall, secondly to endothelial cell dysfunction, and finally to atherosclerosis with free lumen dramatic decrease. Consequently, one assumption is to believe that newly formed tissue viability cannot be reached if mechanical properties of the fibrous scaffold do not mimic those of native tissue and particularly the native vascular wall compliance. 

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