Extended Collander equations

An overview of permeability assays is presented in Table 2.2. As discussed earlier in this chapter, these permeability scales are correlated to each other as well as the various hpophilicity scales via extended Collander equations. 

Only 66% of the variance in the data is explained by this equation. However, a separation of the various solutes into OH bond donors, acceptors, and neutrals helped account for 94%of the variance in the data. These restrictions led Seiler to extend the Collander equation by incorporating a corrective term for H-bondingin the cyclohexane system (119). Fujita generalized this approach and formulated Equation 1.43 as shown below (120). 

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