Extemporaneous Preparation, Handbook

Remington, J.P. The Practice of Pharmacy A Treatise on the Modes of Making and Dispensing Officinal, Unofficinal, and Extemporaneous Preparations, with Descriptions of Their Properties, Uses, and Doses. Intended as as Handbook for Pharmacists and Physicians and a Text-book for Students et seq J. B. Lippincott Company Philadelphia, 1887. 

Regarding Compatibility if components of a prescribed preparation are not compatible (or there is a lack of evidence), it does not mean automatically that it should not be prepared. The preparation needs to show sufficient compatibility up to the in use expiry date it may be possible to produce a preparation with a shortened but useful shelf life. Interactions between the active substances and excipients can however make it impossible to produce a preparatiOTi of sufficient quality. These incompatibilities can be visible or invisible during preparation. The attending pharmacist has to verily if incompatibilities are apparent. More informaticHi about incompatibilities is to be found in references such as Fiedler (Sect. 39.2.2), Handbook of Pharmaceutical Excipients (Sect 39.2.3), Martindale (Sect. 39.2.4), Handbook of Extemporaneous Preparation (Sect. 39.4.6), Konunentar zum Arzneibuch (Sect. 39.4.8) and Trissel s Stability of Compounded Formulations (Sect. 39.4.14). 

Such national formularies are good starting points for formulations as they may have been tested or supported by published or validated formulae. A secrnid example is the German Formulary (Neues Rezeptur-Formularium, see Sect. 39.4.2). In the UK, the Handbook of Extemporaneous Preparation (see Sect. 39.4.6) also lists a selectimi of 50 commonly used formulae, and the British Pharmacopoeia has a small number of formulatirMis detailed. The existence... 

For more extensive information on substances several sources can be useful. Profiles of drug substances excipients and related microbiology. Handbook on extemporaneous preparation and Trissel s Stability of compounded formulations are discussed. 

This handbook has a part on standards for extemporaneous dispensing and a part containing stability summaries for the 50 most frequent extemporaneously prepared medicines in UK NHS hospitals. It also includes sections relating to clinical risk assessment and advice for procuring tmlicensed medicines from manufacturers. 

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