EXSIDE experiment

This facet of the experiment is similar to the EXSIDE experiment developed by Krishnamurthy. Modulation is illustrated by the nature of the responses in the four panels presented in Fig. 12. Segments are shown from four ACCORD-HMBC spectra, each acquired with ni = 128. Panels (a)-(d) were acquired with optimization ranges of 6-10, 4-12, 2-16, and 2-25 Hz, respectively. In Panel (a), no response is observed for the H-I la proton resonating at 3.05ppm. The response correlating H-1 la/C12 is observed in the 4-12 Hz data shown in Panel (b). Note that in the 3-16 and 2-25 Hz data shown in Panels (c) and... 

In 2001, Meissner and Sprensen described methods for the measurement of Jhh anO "Jch couplings employing the broadband excitation approach (see Section 3.3.7) with the report of the broadband XLOC and broadband J-HMBC experiments, respectively. In a further extension of the idea of accordion optimization, Williamson ef reported the development of the J-IMPEACH-MBC pulse sequence. This approach is similar to the EXSIDE experiment previously described by Krishnamurthy and the J-resolved HMBC experiments of Furihata and Seto"- in its use of J-scaling to render small, long-range heteronuclear couplings conveniently measurable. Finally, Williamson e/ also described a new method, G-BIRDr-HSQMBC, that was reported in their survey of the available methods. 

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