Expression of an Insensitive Herbicide Target

This strategy was used to engineer resistance against glyphosate, and imidazoli-nones and sulfonylureas that inhibit acetolactate synthase (ALS), a key enzyme in the biosynthesis of branched chain amino acids. ALS resistant crops have primarily been generated through selection for an herbicide insensitive ALS allele from natural or mutagenized cell or plant populations [3]. 

Expression of an herbicide insensitive target has also been reported to provide resistance to diclofop and sethoxydim (ACCase inhibitors), various dinitroani-lines, and inhibitors of phytoene desaturase, lycopene cyclase and hydroxyphenyl-pyruvate dioxygenase. None of these traits are currently incorporated into commercial products. 

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