Exposure-Response Relationships for Therapeutic Biologic Products

Exposure-Response Relationships for Therapeutic Biologic Products [Pg.295]

The optimal administration of drugs in clinical practice is facilitated by effective application of the principles of clinical pharmacokinetics (PK) and pharmacodynamics (PD). Relationships between drug levels in the systemic circulation and various body compartments (e.g., tissues and biophase) following drug administration depend on factors governing drug absorption, distribution, elimination, and excretion (ADME). Collectively, the study of the factors that govern the ADME processes is termed pharmacokinetics. [Pg.295]

Parameter Small-molecule drugs Biologic products [Pg.297]

Subcutaneous Vascular absorption Vascular and lymphatic Absorption [Pg.297]

Protein binding Non-specific Specific binding (e. g., shed receptors) [Pg.297]