Exposure Characterizations for Lead in Specific Human Populations

Exposure Characterizations for Lead in Specific Human Populations 

Part 2 and its chapters presented the topic of human lead exposure in global and categorical terms, addressing the technical areas of lead intakes, uptakes (absorption), toxicokinetics, integration of toxicokinetics into in vivo disposition in a manner allowing quantitative assessments of lead exposure, etc. In contrast to these broadly descriptive aspects of human Pb exposme, the applied health discipline of quantitative risk assessment requires prescriptive approaches for site-specific, case-specific, and environmental scenario-specific lead exposure characterizations. Data from such specific exposure characterizations are combined with available data for lead dose—response relationships to arrive at some quantitative risk characterization indexed as some endpoint for human health risk. 

Trace Metals and other Contaminants in the Ijivironment, Vcriume 10 

By contrast, virtually all other contaminants identified at hazardous or other waste sites are evaluated for their potential human health risk by evaluating aggregated intakes or uptakes of the substance and comparing these values with some risk criterion level or cancer slope factor metric for noncar-cinogenic and carcinogenic effects, respectively. 

This chapter presents some specific case studies where Pb exposme risks in groups of the highest risk category, young children, were quantified in various ways using either measured or modeled PbB levels. 

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