Experiments Concerning Sensitization to Nickel

Sensitization to nickel is of practical as well as theoretical interest. 

Nickel is also known as an eczema -producing substance, especially in women (suspenders, hooks, earrings, wristwatches etc.). Calnan (1957) even spoke of an epidemic of eczema due to nickel in London. Such incidents seem to have diminished since the widespread use of plastic in place of nickel. 

In contrast to the frequency of eczema caused by nickel in women and to certain remarks in the literature, there are, at least in Switzerland, few workers who are sensitized to nickel. In the nickel workshops of Geneva, we have noticed that some young workers quickly become sensitive and must stop work during their apprenticeship, while others, fortunately the majority, can pursue their trade without harm (N. Hunziker, Musso, 1959). 

In 1926 Walthard had already attempted to sensitize guinea pigs to nickel. 

Coca and Milford (1934) were not able to confirm this sensitization. 

---