Experimental protocols for LDMS detection of malaria

Almost all applications of mass spectrometry in biochemistry and biomedicine require preparation of the samples prior to MS analysis. Sample preparation typically includes a number of steps to purify and concentrate target biomarker analytes. However, heme crystal formation, a unique evolutionary 

For comparison purposes, two other MS systems have been used with in vitro grown parasite cultures. In the first case, a home-built miniaturized linear TOF multi-array analyzer1718 was interfaced to the frequency-tripled output at 355nm of a Q-switched Nd-YAG laser ( Polaris, New Wave Research, Fremont, CA). In this experiment the laser beam was not scanned, and the estimated laser fluence after attenuation was similar to that of the commer- 

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