Exons INDEX

GenelD (Guigo, 1998) at http //wwwl.imim.es/software/geneid/index.html predict splice sites, codons, and exons along the query sequence using PWM. Exons are... 

Figure 56.2 In this figure thyroid peroxidase (TPO) mutations up-to-date are described (http /Mww.hgmd.cf.ac.uk/ac/index.php). They are singie nucieotide substitutions (missense/nonsense) and, in a minority of cases, smaii deietions/insertions or spiicing site mutations. Most mutations are iocated at exons 8, 9 and 14. Exons are drawn to scaie.

Arsenic (As) has been reported In a variety of tissues, any of which are potentially useful as indexes to exposure. However, the organic pentavalent arsenicals are not accumulated in tissues and are rapidly excreted in urine ( - ). Therefore, urine generally is a particularly valuable index to applicator exposure. Exon et al. ( 5) reported both urine and feces were Important pathways of excretion in rabbits exposed to MSMA In their feed. They found 70 of ingested As had been excreted (54% in urine, 46% in feces) during a 17-week exposure period. Arsenic levels in liver, hair, and urine were the same as in controls after 12 weeks of MSMA exposure followed by 5 weeks of control rations. Indicating excretion was ultimately fairly complete. 

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