Stem cells exogenous populations

Hematopoiesis is the process of blood cell production that takes place in the bone marrow. Through a complex series of regulatory events, stem cells are differentiated into various types of cells, including red blood cells. Stem cell differentiation is responsive to exogenous stimuli and can be upregulated to resupply a deficient cell population. However, only a limited number of therapeutics (iron, hemin, or erythropoietin, for example) can stimulate Hb-replete red blood cell formation. Recognition of the poor bioavailability of many iron compounds or hemin compositions and the improved safety profile of a tHb relative to rmmodified Hb has renewed the interest in Hb administration as... 

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