EXHIBIT F Fatal Skin Absorption

Source U.S Department of Labor, Occupational Safety and Health Administration Hazard Information Bulletin 19980309. Available on-line at www.osha.dov/dts/ hib/hib data/hibl9980309.html. Downloaded March 14,2004. 

Once the drug is distributed in the plasma, it can be delivered to tissues, where metabolism and elimination processes begin. It is important to note that metabolism is elimination in the sense that the parent molecule is converted to a new substance, causing Cp of the parent to decrease. The rate of removal of the drug, sometimes referred to as the clearance rate, usually follows first-order kinetics. 

In any first-order process, the rate of the reaction depends only on the concentration of the drug. The half-life is derived by starting with the general equation for a first-order process  

The half-life should carry a descriptive label, such as b, pias, a, for clarity. This notation is also important because a decrease in plasma concentration does not 

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