EXHIBIT D Drug Money

Sources Jenkins, A. J. Drug contamination of US paper currency. Forensic Science International, 121 2001,189-193. Sleeman, R., et al. Drugs on Money. Analytical Chemistry, June 1,2000,397A-403A. 

Assume a sample is delivered to the lab that is suspected to contain cocaine, lido-caine, benzocaine, and procaine. What would be the best method of sample extraction and preparation  

Answer Actually, little sample preparation is needed. All four compoimds tue related and have similar structures, so a LLE or SPE extraction to separate foem from each other is neither feasible nor necessary. A rudimentary sample preparation, such as a dry extract, would be sufficient to allow for TLC wifo standards and GCMS. 

This problem is a reminder that sample preparation does not have to separate every analyte from every other one. Rather, sample preparation should extract the an-al3des from the matrix. If GCMS or other hyphenated techniques will separate the an-al5Ttes, that capability should be exploited. Exhaustive isolation should be undertaken when necessary. 

Applying the Science 8.2 Raman Spectro opy for Mixtures v /lth Diluents 

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