EXHIBIT B Aspirin

The history of aspirin (acelylsalicylic acid) is typical of that of many other drugs and starts with folk knowledge. As early as 400 B.C., the Greek physician Hippocrates recommended that his patients chew on willow bark when they had a fever or pain. It is 

When commercial tablets are made, they are otten marked by a machine called a tablet press, which incorporates a die that presses letters, symbols, or logos into the tablet s surface. As a consequence, toolmarks are created by the die in the surface of the tablet. Illicit chemists often use tablet 

In some cases, these toolmarks can be useful in profiling counterfeit preparations. In a recent paper, researchers used near-infrared spectroscopy to evaluate commercial tablets that 

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A Dendrogram for the hierarchical analysis of second-derivative spectra of the front (case with odd numbers) and back face (case with even numbers) of a 58.82% caffeine tablet. Reprinted with permission from source 2, copyright 2004 American Chemical Society. 

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