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Excretion creatinine clearance equation

Digoxin is not extensively metabolized in humans almost two thirds is excreted unchanged by the kidneys. Its renal clearance is proportional to creatinine clearance. Equations and nomograms are available for adjusting digoxin dosage in patients with renal impairment. [Pg.295]

In Equation 1.36, Dg is the adjusted maintenance dose for the patient with renal failure, D is the maintenance dose for a normal individual,/is the fraction excreted, and C/r is the patient s creatinine clearance, which can be determined from the serum creatinine value using the Cockcroft and Gault Equation 1.42. If a new dosing interval for the patient with renal failure (x ) is calculated, a reciprocal of the bracketed term in Equation 1.45 is used and the new equation becomes Equation 1.46. ... [Pg.25]

See other pages where Excretion creatinine clearance equation is mentioned: [Pg.115]    [Pg.5]    [Pg.16]    [Pg.1257]    [Pg.188]   
See also in sourсe #XX -- [ Pg.188 ]



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