Excretion breast cancer resistance protein

Biliary Excretion Mediated by Breast Cancer-Resistant Protein (BCRP)... 

In contrast to P-gp and the MRP proteins, the breast cancer resistance protein (BCRP) contains six transmembrane domains and only one ATP-binding domain. It was first cloned from the breast cancer cell line MCF-7 selected in doxombicin, in the presence of the P-gp inhibitor verapamil. It is found in many human tissues, such as the placenta, small intestine, colon, and liver [133], It is localized to the apical membrane of epithelial cells of the small intestine and colon and to the bile canalicular membrane in the liver and is involved in reducing intestinal uptake, increasing hepatobiliary excretion, etc., leading to diminished oral bioavailability. cDNA sequences identical to BCRP and named MXR and ABCP, respectively, were independently isolated from human colon carcinoma cells and human placenta [134], BCRP requires... 

G. Merino, J. W. Jonker, E. Wagenaar, A. E. van Herwaarden, and A. H. Schinkel. The breast cancer resistance protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin. Mol Pharmacol 67 1758-1764 (2005). 

Mizuno N, Suzuki M, Kusuhara H, et al. Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (e3040) sulfate in breast cancer resistance protein (bcrpl/abcg2) knockout mice. Drug Metab Dispos 2004 32 898-901. 

Ando, T., Kusuhara, H., Merino, G., Alvarez, A.I., Schinkel, A.H. and Sugiyama, Y. (2007) Involvement of breast cancer resistance protein (ABCG2) in the biliary excretion mechanism of fluoroquinolones. Drug Metabolism and Disposition The Biological Fate of Chemicals, 35, 1873-1879. 

Recent evidence suggests that excretion of ochratoxin A into human milk is mediated by breast cancer resistance protein (BCRP). BCRP is a member of the ATP-dependent efflux transporter family, which is highly expressed during lactation in various species, including humans, and is known to be responsible for the excretion of various drugs and xenobiotics into milk (Jonker et al., 2005 Schrickx... 

Mizuno N, Takahashi T, Kusuhara H, Schuetz JD, Niwa T, and Sugiyama Y (2007) Evaluation of the role of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated protein 4 (MRP4/ABCC4) in the urinary excretion of sulfate and glucuronide metabolites of Edaravone (MCI-186 3-Methyl-l-phenyl-2-pyrazolin-5-one) Drug Metab Dispos 35 2045-2052. 

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