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Halide-lithium exchange

Chlorohydrins epoxides. Chloromethyllithium is thermally unstable, but can be obtained by reaction of lithium wire with bromochloromethane. The halide-lithium exchange is markedly accelerated by sonication [(( ], which also promotes a subsequent reaction of the chloromethyllithium with an aldehyde or a ketone to form epoxides via chlorohydrins.1 Overall yields are 70-90%. [Pg.83]

Because the free energy of the aryl halide/lithium exchange equilibrium is essentially equal to the enthalpy change of the reaction, we consider other reactions from the same source of the general type (equation 11),... [Pg.130]

It can also be obtained by halide-lithium exchange by reaction of (Z)-BrCH=CHOC2Hs with n-butyllithium. [Pg.420]

SELECTIVE HALOGEN-LITHIUM EXCHANGE REACTIONS OF 2- 2 -HAL0PHENYL)ETHYL HALIDES ... [Pg.74]

Coupling of certain lithiated reagents with aryl and vinyl halides is also possible.82 These reactions probably proceeds by a fast halogen-lithium exchange, generating the alkyl halide, which then undergoes substitution. This reaction has been applied to P-lithiobenzamides.83... [Pg.636]

See other pages where Halide-lithium exchange is mentioned: [Pg.5]    [Pg.450]    [Pg.941]    [Pg.942]    [Pg.958]    [Pg.958]    [Pg.959]    [Pg.972]    [Pg.224]    [Pg.549]    [Pg.759]    [Pg.68]    [Pg.68]    [Pg.65]    [Pg.46]    [Pg.242]    [Pg.252]    [Pg.233]    [Pg.68]    [Pg.29]    [Pg.128]    [Pg.14]    [Pg.219]    [Pg.143]    [Pg.110]    [Pg.66]    [Pg.114]    [Pg.525]    [Pg.537]    [Pg.538]    [Pg.807]    [Pg.632]    [Pg.632]    [Pg.93]    [Pg.138]    [Pg.91]    [Pg.91]    [Pg.384]    [Pg.448]    [Pg.473]    [Pg.34]    [Pg.232]    [Pg.47]   
See also in sourсe #XX -- [ Pg.28 ]



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Alkyllithium-lithium halide exchange reactions

Halide exchange

Halide-lithium exchange reactions

Halide-lithium exchange reactions metalation

Halide-lithium exchange reactions quenching

Halides lithium

Halogen-Lithium Exchange with Organic Halides

Lithium-halogen exchange aryl halide

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