Examples of species differences in drug sensitivity

ICH S7A ICH Harmonized Tripartite Guidelines on Safety Pharmacology Studies for Human Pharmaceuticals, 2001. 

Thatte, L., and Vaamonde, C.A., Drug-induced nephrotoxicity. Postgrad. Med., 1996,100 83-100. 

Guidance for Industry Pharmacokinetics in Patients with Impaired Renal Function—Study Design, Data Analysis, and Impact on Dosing and Labeling, Draft Guidance, Rockville, MD FDA, March, 2010. 

Hoffman, D., et al.. Performance of novel kidney biomarkers in prechnical toxicity studies, Toxicol. Sci., 2010,116 8-22. 

Cockroft, D.W., and Gault, M.H., Prediction of creatinine clearance from serum creatinine. Nephron, 1976,16 31—41. 

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