Examples of pathways

Though SMSl can activate RESPl alone in allr013A, that means without help of TS(xlly) this is not possible in a22r013A. Here it needs the help of TS(x22y). Why Hypotheses  

If TS(x22y) searches for the stimulus element, it scans the basic elements less frequently than in the task set TS(xlly), the basic elements are less reagible und need therefore the support of awareness (=triple search). 

The reverse case, that xlly uses triple search and x22y double search, is present in vllrO05A and v22rO05A. The awareness interpretation would explain this by the reduction of awareness from xlly to x22y. 

If one takes ET(vllrH01C)=17ms, (Fp-con)=50ms contains only 3 linET and (Med-Fp)=35ms contains only 2 cycET. 

Here (Fp-con) contains 4 linET and (Med-Fp) contains 3 cycET, that means the linear part is 2 ET long and the cyclical part 5 ET. 

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Bis(tnfluoromethyl)-subsntuted hetero-1,3-dienes and acetylenes react to give open-chain tnfluoromethyl-substituted N-propargylic amides, 4//-1.3 oxazines, and 2-oxazohnes [42,144] The formation of 2-oxazolmes is an example of pathway 2 (equabon 25), where only one carbon atom of the acetylene moiety IS incorporated into the new nng system The selectivity of this reaction can be controlled efficiently in favor of the five-membered nng system by altering the reaction conditions In the presence of 4-dimethylaminopyndine, the five-mem-... 

An example for location 2 would be sulfuric acid, which, without being metabolized, would indiscriminately destroy nucleic acid and protein, regardless of genetic differences. Reactive metabolites, as potent electrophiles, presumably seek out macromolecular nucleophilic sites in a random fashion covalent interaction of small reactive metabolities with DNA is therefore an example of location 6. The chemical rearrangement of a reactive epoxide to a less reactive phenol would also occur nonenzymatically this is an example of pathway 7. 

The reaction of sulfoxide (147) with thionyl chloride, which produces a,p-dichlorosulfides (148 Y = W = Cl) in 85-95% yields, is an example of pathway 1. Illustrating pathway 2 is the remarkable enantiospecific formation of lactone (150) from the reaction of dichloroketene with the chiral sulfoxide (149 equation 28). ° ... 

Fig. 5.21 Examples of pathways to saturated hydrocarbons from bacteriohopanetetrol (large arrows indicate biogenic input). The A, B and C rings of hopanes and hopanoic acids are omitted but are identical to those of the C35 tetrol precursor (R = H to C6H13 after Schmitter et al. 1982 Mackenzie 1984 Brassell 1985).

TT-Allyl and related complexes can be prepared by reactions such as 23.81-23.85 the last two reactions illustrate formation of allyl ligands by deprotonation of coordinated propene, and protonation of coordinated buta-1,3-diene respectively. Reactions 23.82 and 23.83 are examples of pathways that go via a-bonded intermediates (e.g. 23.48) which eliminate CO. 

An example of pathway modification (the second type) is the production of w ra-substituted amino acids such as 3(3-carboxyphenyl)alanine (8) via a modified shikimic acid pathway (Fig. 13.3) (Bell, 1976). 

There have been many examples of creating new metabolic pathways in bacterial systems, but more recently there has been an increase in the examples of pathway manipulation for medical applications. 

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