Evolution of Natural Products

The formation of new, more effective molecular systems by the interaction of two (or more) precursors, each of them already endowed with its own evolutionary history, has an analogy on the level of organisms. According to the endosym-biotic theory defended by Margulis (53), several classes of cellular organelles --mitochondria, plastids, and even perhaps flagella - had once been free-living bacteria that were acquired symbiotically and in a certain sequence by host prokaryotes. 

This is then the greatest show on earth At the start of RNA-based life, the first and presumably simplest organism had stored in itself all the necessary information to construct you and me if - but what an if - during close to 4 billion years the environmental conditions, including catastrophic events (20), had evolved precisely as they did. 

2 Expansion of the Acetate, Mevalonate, and d-Aminolevulinate Pathways in Bacteria and Algae 

In order to formulate the sequences of organic reactions that occurred in organisms, and hence to contribute to the understanding of nature, only living forms can, of course, be analyzed. However, extrapolation of the data to past organisms is a valid procedure because of fossil links, fixedness of the central biochemical, uniformly RNA-based theme and the implied (10) use of CO2 via photosynthesis as the carbon source even in the most primitive organisms. 

On the primitive earth most of the oxygen liberated by Cyanobacteria through the classical reaction (86) 

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Evaluation of the nature of geochemical evidence for the evolution of natural products first requires assessment of e various factors that determine limitations on the chemical nature and information content of sedimentary organic matter (9). These issues bear on a broader range of concerns, including ... 

Krchnak V, Waring KR, Noll BC, MoeUmann U, Dahse M, Miller MJ. Evolution of natural product scaffolds by acyl-and arylnitroso hetero-diels-alder reactions new chemistry onpiperine. J. Org. Chem. 2008 73 4559 567. 

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