Events in Epithelial Injury

Only few detailed analyses of the intracellular events following epithelial injury have been performed using cells from the airways, and most mechanistic work has concentrated on pre-necrotic and necrotic processes in epitheUal cells of renal origin (Trump etal., 1980, 1981 Trump and Berezesky, 1984). Collectively these studies, which have employed a wide range of stimuli to evoke cellular injury (ischaemia, metabolic poisons, chaotropic agents and ionophores), suggest that similar patterns of intracellular events accompany injury evoked by the different stimuli. 

An early intracellular response to epithelial injury appears to involve an increase in intracellular Ca which coincides with the failure of the cells to regulate Na  

Much of the intracellular response to epithelial injury remains to be defined. The mechanistic hnkages between those ionic and morphological changes that have been 

Cell-derived Mediators Implicated in Epithelial Injury 

The ability of oxidant gases (e.g. sulphur dioxide, ozone, nitrogen oxides and complex mixtures of such in 

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