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Evaporation metastable zone

Figure 8-6 A concentration profile for uncontrolled crystallization by evaporation (initial procedure in Example 8-1. The seed was charged to a highly supersaturated solution which may exceed the metastable zone boundary. The metastable zone width was not measured, so this figure is used only for illustration purposes. Figure 8-6 A concentration profile for uncontrolled crystallization by evaporation (initial procedure in Example 8-1. The seed was charged to a highly supersaturated solution which may exceed the metastable zone boundary. The metastable zone width was not measured, so this figure is used only for illustration purposes.
The temperature stability profile of imipenem effectively niles out cooling or evaporative crystallization. Antisolvent addition is the obvious choice. The preferred solvent is water because of the need for sterile filtration of the solution to be fed to the crystallizer. A good antisolvent is known to be acetone. In this case, the antisolvent has the important function of reducing the metastable zone width as well as the solubility. [Pg.239]

The metastable zone width is in case independent of the technique with which the supersaturation is generated. Figure 2.26 shows a system in which the width is nearly the same for a cooling and evaporative crystallization. Note the dispersion... [Pg.23]

See other pages where Evaporation metastable zone is mentioned: [Pg.1667]    [Pg.837]    [Pg.180]    [Pg.1488]    [Pg.1987]    [Pg.597]    [Pg.175]    [Pg.52]    [Pg.53]    [Pg.1975]    [Pg.242]    [Pg.1671]    [Pg.358]    [Pg.527]    [Pg.24]    [Pg.417]    [Pg.292]    [Pg.39]    [Pg.296]    [Pg.18]   
See also in sourсe #XX -- [ Pg.167 , Pg.168 , Pg.170 ]



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