Eupenicillium brefeldianum

Another natural product, mizoribiae (39), a nucleoside antibiotic produced by the fungus Eupenicillium brefeldianum has cytotoxic and immunosuppressive activity. It has been evaluated for use ia renal transplantation and neoplasia (68). 

Bredinin, Neosidomycin, and SF-2140. Bredinin (62), isolated from the culture filtrates of Eupenicillium brefeldianum (1,4), inhibits the multiplication of L5178Y, HeLa S3, RK-13, mouse L-ceUs, and Chinese hamster cells. GMP can reverse the inhibition by (62), but (62) is not incorporated into the nucleic acids. The inhibition of nucleic acid synthesis and chromosomal damage in the S and G 2 phases that is caused by (62), is reversed by GMP. It blocks the conversion of IMP to XMP and XMP to GMP. In combination with GMP, (62) interferes with intracellular cAMP levels and thereby inhibits cell division. 

Watanabe M et al (2005) Cloning and characterization of saponin hydrolases from Aspergillus oryzae and Eupenicillium brefeldianum. Biosci Biotechnol Biochem 69(11) 2178 Osbourn A (1996) Preformed antimicrobial compounds and plant defence against fungal attack. Plant Cell 8 1821... 

Bredinin, Neosidomycin, and SF-2140. Bredinin (CiyH NjO, ) isolated from the culture filtrates of Eupenicillium brefeldianum, inhibits the multiplication of L5I78Y, HeLa 83, RK-13, mouse L-cells, and Chmese hamster cells. 

Isolation from cultures of Eupenicillium brefeldianum NRRL 5734. a Amberlile IRA-411/pH 10. b Chromatography on DEAE-Sephadcx A-25. 

Emericella nidulans (ana. Aspergillus nidulans) Eupenicillium brefeldianum (ana. Penicillium... 

Penicillium dodgeii (tel. Eupenicillium brefeldianum) Periconia abyssa Phialophora fastigiata... 

---