Ethylene derivs 1,2-disulfonates

Ethylene derivs. from 1,2-disulfonates C(0S02R)C(0S02R) C C... 

The base-catalyzed additions of glyoxal to formamide and methanesulfonamide afforded 1,4-diformyl- (895, 1663) and l,4-bis(methylsulfonyl) derivatives (895) of 2,3,5,6-tetrahydroxypiperazines, respectively, in addition to the corresponding A iV -disubstituted 1,2-diamino-l, 2-ethanediols (895). Salts of 2,3,5,6-tetrahydroxy-piperazine-l,4-disulfonic acid were similarly prepared by the addition of aqueous glyoxal to sulfamic acid in the presence of base (1664). Ethylene dichloride with hydrazine in ethanol gave ethylene dihydrazine, 1,4-diaminopiperazine, and poly(ethylenehydrazine) (1665). 

Finally MacDonald and Fischer have prepared the free ajyZo-pento-dialdose (8) by the sulfone-degradation method. The diethyl dithioacetal of scyllo-inosose (12) was oxidized to the corresponding disulfone which, on treatment with ammonia, gave the dialdose (8). The structure was proved by converting the compound into the bis(ethylene dithioacetal) derivative, which was identical with that obtained from a /io-pentodialdose prepared by a previous method. ... 

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