Ethyl pyromeconic acid

SYNS 2-ETHYL-3-HYDROXYAH-PYRAN-4-ONE 2-ETHYL PYROMECONIC ACID 3-HYDROXY-2-ETHYL-4-PYRONE... 

ETHYL PYROMECONIC ACID see EMA600 N-ETHYLPYRROLIDINONE see EPC700... 

Ethyl pyromeconic acid 3-hydroxy-2-ethyl-4-pyrone Veltol Plus. 

Synonyms 2-Ethyl-3-hydroxy-4H-pyran-4-one 2-Ethyl pyromeconic acid 3-Hydroxy-2-ethyl-4-pyrone... 

Ethyl pyromeconic acid. See Ethyl maltol Ethyl pyrophosphate, tetra-. See Tetraethyl pyrophosphate... 

Studies on the tautomerism of heterocycles, including pyrans and derivatives, have been extensively reviewed <2006AHC(91)1>. Computational studies have been used to examine a number of 3-hydroxy-4-pyranones such as maltol 68, ethyl maltol 69, and pyromeconic acid 70, and it has been determined that the 3-hydroxy-4-oxo tautomer is the most stable <2003JMT(639)87>. 

The first successful synthesis of maltol started from pyromeconic acid, which itself was an expensive material, and gave maltol in low yields. Today, industrial production is carried out by fermentation (kojic acid produced by an Aspergillus fungus) combined with chemical synthesis [10,20]. The synthetic routes include oxidation of kojic acid and addition of formaldehyde. By substituting acetaldehyde for formaldehyde, ethyl maltol (Fig. 3.60) is produced [20]. 

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See also in sourсe #XX -- [ ]

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