Ethyl dimethylphosphoramidofluoridate

Ethyl dimethylphosphoramidofluoridate (VIII) was prepared by a similar method and proved to be a very toxic liquid. Its l.d. 50, on intravenous injection into rabbits and also on subcutaneous injection into mice, was 2-5 mg./kg. Toxicity was also determined by inhalation and a Ct ((7 = concentration, <=10 min.) of 200 mg./min./cu.m. killed seven out of a batch of eleven rabbits, guinea-pigs, rats and mice a Ct of 100 mg./min./cu.m. killed four out of eleven. The compound also possessed myotic properties. Other compounds that we made in this series were much more toxic and it will be seen that they bear some resemblance to tabun and sarin now about... 

Diisopropylamino)ethyl Ethyl Methylphosphonite 2-Dimethylaminoethyl N,N-Diethylphosphoramidofluoridate 2-Dimethylaminoethyl N,N-Dimethylphosphoramidofluoridate 2-Dimethylaminoethyl N,N-Dimethylphosphoramidofluoridate Methiod ide 2-Dimethylaminopropyl /V,/V-Diethylphosphoramidofluoridate 2- [Ethoxy(ethyl)phosphoryl]sulfanyl -N/N/N-triethylethanaminium Iodide 2- [Ethoxy(ethyl)phosphoryl]sulfanyl -N/N/JV-trimethylethanaminium Iodide... 

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