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Ethyl dibromofluoroacetate

Other a-fluorinated carboethoxy substrates have been utilized in Reformatsky reactions. Treatment of ethyl dibromofluoroacetate with aldehydes or ketones in presence of zinc and EtaAlCl gave diastereomeric a -brorno-a-fluoro /i-hydroxyalkanoic esters in good yield (49-77%) (equation 120)177. Use of 2 equivalents each of RCHO, Zn and Et2AlCl gave the double coupled products in good yield. [Pg.750]

Ethyl dibromofluoroacetate has been used as a fluoroacetate enolate equivalent in Reformatsky chemistry developed by the Kyoto group [178]. Addition mediated by zinc and chloro diethylaluminium occurs with modest stereoselectivity to afford the bromofluoro hydroxyesters. [Pg.156]

Analogous reaction of ethyl dibromofluoroacetate with 2-bromopyrunidine 534 gave the corresponding product 535 in low yield (12 %) (Scheme 104) [274],... [Pg.381]

Scheme 104 Coupling of 2-btomopyrimidine with ethyl dibromofluoroacetate... Scheme 104 Coupling of 2-btomopyrimidine with ethyl dibromofluoroacetate...
See other pages where Ethyl dibromofluoroacetate is mentioned: [Pg.122]    [Pg.155]    [Pg.419]    [Pg.95]    [Pg.90]    [Pg.33]    [Pg.90]    [Pg.111]    [Pg.39]    [Pg.122]    [Pg.155]    [Pg.419]    [Pg.95]    [Pg.90]    [Pg.33]    [Pg.90]    [Pg.111]    [Pg.39]   
See also in sourсe #XX -- [ Pg.87 ]



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Dibromofluoroacetate

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