6- Ethyl-3- Asthma, effect

This group of chemicals, which are found naturally in many fruits, are used as preservatives, a function that they also perform within fruit. Benzoic acid itself may be used, or more commonly sodium benzoate (a salt) or ethyl or methyl para-hydroxybenzoate, also known as parabens. They have sometimes associated with adverse effects. Anaphylaxis-like reactions have been reported as well as urticaria. About 4 per cent of people who suffer from asthma may experience breathlessness and wheezing when exposed to benzoates. Parabens are often used as preservatives cosmetics. 

Other calorimetric studies [22] on human blood platelets were performed in order to clarify the mechanism of action of xanthine derivatives in relation to adenosine receptor. In addition, there were investigations on the effect of adenosine and adenosine agonists on platelet metabolism. The results showed that the two xanthine derivatives tested, enprofylline and theophylline, at therapeutic concentrations, did not modify the heat production induced by adenosine. Both adenosine and one adenosine agonist, NECA (5-N-ethyl carboxamide adenosine) increased platelet metabolism. The other adenosine agonist tested, PIA (L-N -phenylisopropyl-adenosine) induced a reduction of heat production. The adenosine uptake inhibitor, dipyridamol, was without effect. Thus, by microcalorimetry, useful information could be obtained concerning the complex mechanisms behind the effects on human cell metabolism of adenosine and adenosine agonists. The same applies to substances used in the treatment of asthma, xanthine derivatives they are thought to act by inhibition of adenosine receptors. 

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