Ethrane - Enflurane

Enflura.ne, Enflurane or Ethrane, 2-chloro-l,l,2-tri luoroethyl difluoromethyl 3838-16-9] was synthesized in 1963. This agent is a mildly... 

Enflurane (Ethrane) is a volatile liquid anesthetic that is delivered by inhalation. Induction and recovery from anesthesia are rapid. Muscle relaxation for abdominal surgery is adequate, but greater relaxation may be necessary and may require the use of a skeletal muscle relaxant. Enflurane may produce mild stimulation of respiratory and bronchial secretions when used alone Hypotension may occur when anesthesia deepens. 

Enflurane has practically all the same characteristics as halothane and is used in the same sitnations. It is poorly absorbed. It is also prescribed under the name ethrane. 

Enflurane (Ethrane) depresses myocardial contractility and lowers systemic vascular resistance. In contrast to halothane, it does not block sympathetic reflexes, and therefore, its administration results in tachycardia. However, the increased heart rate is not sufficient to oppose enflurane s other cardiovascular actions, so cardiac output and blood pressure fall. In addition, enflurane sensitizes the myocardium to catecholamine-induced arrhythmias, although to a lesser extent than with halothane. Enflurane depresses respiration through mechanisms similar to halothane s and requires that the patient s ventilation be assisted. 

Desflurane [Suprane] Enflurane [Ethrane] Halothane [Fluothane] Isoflurane [Forane] Methoxyflurane [Penthrane] Sevoflurane [Ultane]... 

D Enfluran-Pharmacia Ethrane (Abbott 1976) USA Ethrane (Ohmeda)... 

Cunitz G, Danhauser I, Grass P. Die Wirkung von Enflurane (Ethrane) im Vergleich zu Halothan auf den mtracraniellen Druck. [Effect of enflurane (Ethrane) on intracranial pressure in comparison with halothane.] Anaesthesist 1976 25(7) 323-30. 

Enflurane (ethrane, others Figure 13-3) is a clear, colorless liquid at room temperature with a mild, sweet odor It is volatile and must be stored in a sealed bottle but is nonflammable and nonexplosive in mixtures of air or oxygen. 

Enflurane (Ethrane) Most potent myocardial depressant, i cardiac output, systemic vascular resistance, yet slows heart rate, t right atrial pressure, sensitizes myocardium to catecholamines. Most potent suppressor of ventilation control. Less bronchodilation than halothane. Effects on secretions similar to halothane. 

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