Ethoxyquin metabolism

Buetler TM, Gallagher EP, Wang C, Stahl DL, Hayes JD, Eaton DE. Induction of phase I and phase II drug-metabolizing enzyme mRNA, protein, and activity by BHA, ethoxyquin, and oltipraz. Toxicol Appl Pharmacol 1995 135 45-57. 

Ellis EM, Judah DJ, Neal GE, Hayes JD. An ethoxyquin-indueible aldehyde reduetase from rat liver that metabolizes aflatoxin Bi defines a subfamily of aldoHceto reductases. Proc Natl Acad Sci USA 1993 90 10350-10354. 

Before leaving the subject of calcium homeostasis, it is perhaps worth mentioning that some inducers of the hepatic hydroxylating enzymes involved in detoxication (see below) can cause osteomalacia on chronic administration. Such enzyme inducers include the antioxidant ethoxyquin and some anticonvulsant drugs. Their mode of action is far from clear but possibly results from their effects on metabolism of vitamin D in the liver. 

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