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1 -Ethoxycarbonyl-4-piperidone

Similar intermediates including o-ethoxycarbonyl-, o-cyano- and o-dimethyl-aminomethylene-piperidones or their imines have been used to give partially reduced analogues, e.g. (244), in the [2,3-. [Pg.228]

A solution of 1-benzyl-4-piperidone, ethyl cyanoacetate, powdery sulfur and morpholine in ethanol is heated moderately under reflux for about 20 minutes to dissolve the powdery sulfur. The mixture is heated under reflux for one further hour to complete the reaction. On standing at room temperature, the mixture yields a precipitate. The precipitate is collected by filtration, washed well with methanol and recrystallized from methanol to give 2-amino-6-benzyl-3-ethoxycarbonyl-4,5,6,7-tetrahydrothieno(2,3-c)-pyridine as almost colorless needles melting at 112° to 113°C. [Pg.1493]

Similar reactions were carried out with 4//-tetrahydropyran-4-one, l-ethoxycarbonyl-4-piperidone, 4-alkylcyclohexanones, and 1,4-dioxa-spiro[4,5]decan-8-one to give the corresponding aminomethylenemalonates (278, X = O, NCOOEt, MeCH, EtCH, (CH,0),C) (86EUP168350 87USP4647566). [Pg.79]

A number of reduced pyrazolo[3,4-c]pyridines have been prepared by cyclization of 3-piperidones substituted in the 4-position. For example, reaction of 4-ethoxycarbonyl- or 4-cyano-3-piperidones (125 X = C02Et or CN) with hydrazine afforded the pyrazolones 126a (R1 = H)119 or amines 127,120 respectively. [Pg.368]

A mixture consisting of 2-chlorobenzoylacetonitrile (0.178 mol), A-ethoxycarbonyl-4-piperidone (0.178 mol), sulfur (0.21 mol), and 15.65 ml morpholine in 190 ml methyl alcohol was refluxed 2 hours, then cooled. The precipitate that formed was filtered, then washed with diethyl ether, and 43 g product isolated as a yellow solid. The filtrate was then concentrated and the residue purified by chromatography with silica gel using hexane/EtOAc, 4 1. The solid was recrystallized in methyl alcohol and the product isolated in 81% yield as pale yellow prisms, mp = 194—195°C. [Pg.404]

The classical ring expansion routes into diazepinones by the Schmidt or Beckmann reactions continue to be used. The Schmidt reaction on l-ethoxycarbonyl-4-piperidone at 0°C produced the corresponding hexahydrodiazepinone derivative in 70% yield <91TL2469>. [Pg.179]

A soln. of anthranilic acid and SOClg in dry benzene refluxed 2 hrs., the solvent evaporated at 25° under reduced pressure to afford an intermediate sulfinamide anhydride derv., a soln. of 3-ethoxycarbonyl-2-piperidone in dry benzene added, and allowed to stand at room temp, overnight 6-ethoxycarbonyl-6,7,8,9-tetra-... [Pg.95]


See other pages where 1 -Ethoxycarbonyl-4-piperidone is mentioned: [Pg.2373]    [Pg.2376]    [Pg.780]    [Pg.97]    [Pg.232]    [Pg.376]    [Pg.236]    [Pg.1015]    [Pg.758]    [Pg.199]    [Pg.2376]    [Pg.1015]    [Pg.758]    [Pg.403]    [Pg.398]    [Pg.592]    [Pg.143]    [Pg.235]   


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4 -ethoxycarbonyl

Ethoxycarbonylation

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