2- Ethoxy-6-methylpyrazine

Ethoxy-/V-methyl-2-pyrazinecarboxamidine 2-Ethoxy-3-methylpyrazine 4-oxide... 

A large number of 2-alkyl-3-methoxypyrazines has been isolated from raw vegetables (59, 60, 64, 65, 69, 80, 1099), bell peppers (60,61) and gambanum oil (49). 2-Isobutyl-3-methoxypyrazine is already finding commercial use as a flavoring material (368) and 2-ethoxy-3-methylpyrazine may be used for pineapple flavor (981). The odor characteristics (367, 368, 976, 977) and structure (977) of some alkoxy alkylpyrazines have been examined. 3-Guanidino-6-hydroxymethyl-l-methyl-2-oxo-l,2-dihydropyrazine has been isolated from seeds of Stizolobium hassjoo and on mild alkaline hydrolysis gave 3-hydroxy-6-hydroxymethyl-l -methyl-2-oxo-l, 2-dihydropyrazine (1060). 

Chloromethyl-3-ethoxy-5-methylpyrazine 2-Chloromethyl-3-methoxy-5-methylpyrazine 1-oxide 2-Chloromethyl-3-methylpyrazine... 

Ethoxy-5,6-diphenyl-2-pyrazinecarbonitrile 2-Ethoxy-3-ethoxymethyl-6-methylpyrazine 2-(l-Ethoxyethyl)-3-ethylpyrazine 2-Ethoxy-3-ethylpyrazine... 

Hydrolysis of 2-chloromethyl-3-ethoxy-5-methylpyrazine with aqueous potassium hydroxide gave 3-ethoxy-2-hydroxymethyl-5-methylpyrazine (872), but attempted acid hydrolysis of 2-chloromethyl-3-ethoxy-5-methylpyrazine (and 3-ethoxy-2-ethoxymethyl-5-methylpyrazine) was unsuccessful (872). Attempts to convert 2-chloromethylpyrazine to 2-hydroxymethylpyrazine were also unsuccessful (679). 

The following alkoxypyrazine Af-oxides have been prepared from the corresponding chloropyrazine A-oxides and sodium alkoxide in the appropriate alcohol (unless otherwise specified) 3-methoxypyrazine 1-oxide (838) 2-methoxypyrazine 1-oxide (no details (838) 3-ethoxypyrazine 1-oxide (978) 3-ethoxy-2-methylpyrazine 1-oxide (potassium hydroxide in ethanol) (978) 3-ethoxy-2,5-dimethylpyrazine 1-oxide (sodium ethoxide or potassium hydroxide in ethanol) (872, 978) and 3-methoxy-2,5-dimethylpyrazine 1-oxide (588). 

Alkoxypyrazine A-oxides may also be prepared by oxidation of the alkoxypyrazine with peroxyacetic acid. In this way the following have been prepared 3-ethoxypyrazine 1-oxide (100°/20h) (978) 3-(trideuteromethoxy)pyrazine 1-oxide (757l9h) (975) 3-ethoxy-2-methylpyrazine 1-oxide (65-75724h) (978) 3-methoxy-2-phenylpyrazine 1-oxide (55720 h) (817) 3-ethoxy-2,5-dimethyl-pyrazine 1-oxide (56716 h) (872) 3-carbamoyl-2-methoxypyrazine 1-oxide (80720h) (881) and 2-cyano-5-ethoxy-3,6-dimethylpyrazine A-oxide (55720h) (288). 

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