Ethosuximide vigabatrin

Figure 16.7 The structure of some established antiepileptic drugs (AEDs) and some newer ones. Note that while the structures of phenytoin and ethosuximide are similar and also close to that of phenobarbitone, they are effective in different forms of epilepsy. Vigabatrin, progabide and gabapentin are clearly related to GABA. Muscimol is a GABAa agonist but is not an effective antiepileptic drug...

Antiepileptics Phenytoin Carbamazepine Valproic acid Gabapentin Vigabatrin Ethosuximide Benzodiazepines... 

Barbiturates phenobarbital 1 Benzodiazepines alprazolam, diazepam, i lorazepam, oxazepam Carbamazepine, ethosuximide, valproic acid, phenytoin, diazepam, lorazepam, gabapentin, lamotrigine, felbamate, topiramate, tiagabin, vigabatrin... 

Carbamazepine s mechanism of action is similar to that of phenytoin, blocking sodium ion channels. Ethosuximide blocks calcium channels benzodiazepines and barbiturates facilitate the inhibitory actions of GABA topiramate may block glutamate receptors and vigabatrin inhibits GABA metabolism. The answer is (A). 

Noninterfering carbamazepine, carbamazepine dihydrodiol, carbamazepine epoxide, N-desmethylsuximide, ethosuximide, lamotrigine, loreclezole, monohydroxycarba-mazepine, phenobarbital, phenytoin, primidone, valproic acid, vigabatrin... 

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