Behavioral changes ethosuximide

Ethosuximide Ataxia Blood dyscrasias Behavior changes... 

The most common dose-related adverse effect of ethosuximide is gastric distress, including pain, nausea, and vomiting. When an adverse effect does occur, temporary dosage reductions may allow adaptation. Other dose-related adverse effects are transient lethargy or fatigue and, much less commonly, headache, dizziness, hiccup, and euphoria. Behavioral changes are usually in the direction of improvement. 

Clonazepam is well absorbed, 95 to 98% protein bound, and extensively metabolized by CYP3A4. Clonazepam displays a wide spectrum of antiseizure activities and is one of the most potent AEDs. Side effects are common, however, and the development of tolerance is more frequent than with ethosuximide or valproate. Sedation is prominent, especially early in treatment. Drowsiness, ataxia, and behavioral changes may be disabling, but slowly Increasing its dose over a 2-week period Is recommended to minimize adverse effects. Diplopia, headaches, nystagmus, and other neurologic effects have been reported with the use of clonazepam. 

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