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Ethinylestradiol Paracetamol

Rogers SM, Back DJ, Orme MLE (1987) Intestinal metabolism of ethinylestradiol and paracetamol in vitro studies using Ussing chambers. Br J Clin Pharmacol 23 727-734. [Pg.212]

Paracetamol might have a similar effect to ascorbic acid, that is competition with ethinylestradiol for sulfation capacity in the gut. Paracetamol significantly reduced the AUC of ethinylestradiol sulfate but had no effect on plasma levonorgestrel concentrations... [Pg.242]

In six healthy women, a single dose of paracetamol 1 g significantly increased the AUC of ethinylestradiol by 22% and reduced the AUC of ethinylestradiol sulfate (353). Plasma concentrations of levonorgestrel were unaltered. This interaction could be of clinical significance in women taking oral contraceptives who take paracetamol regularly or suddenly stop taking it, but it is doubtful whether it has any practical repercussions. [Pg.242]

Paracetamol clearance is increased in women taking oral contraceptives, although the clinical relevance of this is uncertain. Paracetamol also increases the absorption of ethinylestradiol from the gut by about 20%. HRT appears not to interact with paracetamol. [Pg.195]

A single 1-g oral dose of paracetamol increased the AUC of ethinylestradiol by 22% in 6 healthy women, and decreased the AUC of ethinylestradiol sulfate by 41%. Plasma levels of levonorgestrel were not affected. ... [Pg.195]

The modest pharmacokinetic interaction between the oral contraceptives and paracetamol appears to be established, but its clinical importance has not been directly studied. The clinical importance of the modest increased ethinylestradiol absorption is also uncertain, but likely to be minor. HRT appears not to interact with paracetamol. [Pg.195]


See other pages where Ethinylestradiol Paracetamol is mentioned: [Pg.97]    [Pg.1669]    [Pg.195]    [Pg.195]    [Pg.382]   
See also in sourсe #XX -- [ Pg.195 ]




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