Etheno deoxycytidine

In a similar biochemically oriented vein, several papers were published during 2003 in the journal Chemical Research in Toxicology, representing yet another area of applicability of 3 mm NMR probe capabilities. In the first of these reports, Hankin et al.159 described the results of an investigation into the covalent binding of leukotriene A4 to DNA and RNA. Later in 2003, Blair and co-workers160 reported on the characterization of 2 -deoxycytidine adducts derived from 4-oxo-2-nonenal, a novel lipid peroxidation product. Two of the adducts characterized, Ai and A2, were consistent with substituted ethano-deoxycytidine structures. The third adduct, B, was characterized as a 7-heptanone-etheno-deoxycytidine adduct (78). 

Vinyl chloride. A chemical used in the manufacture of plastics which is carcinogenic and causes various toxic effects including liver injury, damage to bones and skin. Liver haemangiosarcomas are produced in animals and humans. Vinyl chloride undergoes metabolic activation by cytochrome P-450 to an epoxide which may interact with DNA and form adducts (etheno-deoxyadenosine and etheno-deoxycytidine) which leads to mutations. Also reaction with glutathione occurs. 

D.W. Roberts, M.I. Churchwell, F.A. Beland, J.-L. Fang, D.R. Doerge, Quantitative analysis of etheno-2 -deoxycytidine DNA adducts using on-line immunoaffinity chromatography coupled with LC-ESI-MS—MS detection. Anal. Chem., 73 (2001) 303. 

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