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Ethanolamine antihistaminic agent

It is an ethanolamine antihistaminic agent belonging to the first-generation Hj-antagonist... [Pg.490]

The drug is an ethanolamine antihistamine agent having appreciable sedative pharmacologic activity and, generally, listed in OTC sleep aids. It also possesses significant anticholinergic activity. [Pg.490]

Individuals who have become sensitized by topically applied diphenhydramine can acquire a systemic eczematous contact dermatitis when diphenhydramine or any of the other ethanolamines listed in Table 5 is ingested or injected (Fisher 1973 It is not generally realized that dimenhydrinate (Dramamine) is an ethanol-amine (the chlorotheophylline salt of the antihistaminic agent diphenhydramine). Dimenhydrinate contains between 53% and 56% diphenhydramine and therefore should not be administered to any individual with allergic hypersensitivity to the ethanolamine group of antihistamines. [Pg.384]

Hf and H Receptors. Histamine exerts its actions by binding to receptors on cell membranes. Two types of histamine receptors, the Hi and H2 receptors, are known specific agonists and antagonists exist for each of these receptors. Black et al. (55) differentiated H and H2 receptors with the compounds, 2-methylhistamine and 4 methylhistamine. 2-Methylhistamine is active on tissues with H receptors 4-methylhistamine is active on tissues with H2 receptors. Classical antihistaminic drugs were developed in the 1930 s these compounds block H but not H2 receptors. Among the clinically used H -blockers are derivatives of ethanolamine, ethylenediamine, alkylamine, piperazine and phenothiazine (32). These agents are valuable in the treatment of... [Pg.425]

Ethanolamines—(diphenhydramine was the prototypical agent in this group). Ethylenediamines, which were the first group of clinically effective Hj antihistamines developed, (pyrilamine). [Pg.221]

Of the systemic antihistamines, the ethanolamines, including diphenhydramine, have significant antimuscarinic activity. In addition, the antipsychotic agents, particularly the phenothiazines such as thioridazine (Mellaril), have well-dociunented anticholinergic properties. Therapeutic doses of tricyclic antidepressants, like amitriptyline hydrochloride (Elavil) and imipramine (Tofranil), produce significant anticholinergic actions and thus have the potential for ocular side effects. [Pg.722]

Drugs developed during the 1940s (e.g., pyrilamine and diphenhydramine) were marketed for the treatment of various allergic conditions such as urticaria and hay fever, for which they are still in use. Many additional drugs joined these two pioneering agents. Ultimately, five chemical classes of antihistamines evolved ethanolamine derivatives, eth-ylenediamines, alkylamines, piperazines, and phenothiazine and other polycyclics. Representative examples of each class are illustrated in Table 13-1. [Pg.622]


See other pages where Ethanolamine antihistaminic agent is mentioned: [Pg.108]    [Pg.928]    [Pg.117]    [Pg.622]    [Pg.895]    [Pg.1527]   
See also in sourсe #XX -- [ Pg.490 ]




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