Estrogenicity future developments

Recently, leaders in the pharmaceutical industry have developed a list of desired properties for a fourth generation of SERMs (Table 2). In general, future SERMs must oppose endogenous hormone action in the breast and reproductive system while displaying full estrogenic effects in the cardiovasculature, bone and central nervous systems. Additional criteria are that fourth generation compounds possess superior bioavailability compared with existing SERMs and have... 

Pharmacological management of breast cancer continues to make progress with advanced characterization techniques and the use of aromatase inhibitors and SERMs. Future generations of SERMs will need to be completely devoid of estrogenic activity to prevent the development of resistance, as is occurring with tamoxifen. 

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