Estriol succinate

A mixture consisting of 8 grams of estriol, 20 grams of succinic acid anhydride and 60 ml of pyridine is heated at 90°C for 4 hours, after which the reaction mixture is poured into water. The aqueous solution is extracted with ether, the ether layer is separated, washed with diluted sulfuric acid and after that with water until neutral, then evaporated to dryness to obtain 14 grams of an amorphous substance. Melting point 82° to 86°C. This drying residue proves to consist of a mixture of esbiol disuccinate and estriol monosuccinate, which are separated by repeated crystallization from a mixture of methanol and water. 

Organon Laboratories Limited, England British Patent 879,014 October 4,1961 

Chemical Name [2,3-diehloro-4-(2-methylene-1-oxobutyl)phenoxy] acetic acid Common Name — 

Trade Name Manufacturer Country Year Introduced 

Step A Preparation of 2,3-Dichloro-4-Butyrylphenoxy Acid - The product is prepared using the following ingredients 22.1 grams (0.1 mol) 2,3-dichlorophenoxyacetic acid  

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Estradiol valerate Estramustine phosphate Estriol succinate Polyestradiol phosphate Estradiol-17/3... 

Bts( odium hemisuccinate), C26HMNa209, estriol succinate, Orgastyptin, Stiptanon, Synapause. 

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