Estradiol, constitution

An alternative strategy is to reduce the body s production of estrogen by inhibiting the pathway for its biosynthesis. Aromatase inhibitors, which block the final step in the biosynthetic pathway to the estrogens estrone and estradiol, constitute one such class... 

The remaining steroid lipids constitute two main classes of steroid hormones sex hormones and adrenocortical hormones. The sex hormones include androgens (testosterone, androsterone), estrogens (estrone, estradiol), and progestins (progesterone). The adrenocortical hormones include mineralocorticoids (aldosterone) and glucocorticoids (hydrocortisone). 

Patients with constitutional delay in onset of puberty can be distinguished from those with hypogonadotropic hypogonadism using repeated hCG stimulation. Serum testosterone and estradiol levels rise in the former but not in the latter group. 

Astroff B, Eldridge B, Safe S. 1991. Inhibition of the 17 -estradiol-induced and constitutive expression of the cellular proto-oncogene c-fos by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the female rat uterus. Toxicol Lett 56 305-315. 

Estradiol tamoxifen, ICI Constitutive transactivation Tyr537Asn creates a receptor that displays... 

Masuyama H, Hiramatsu Y (2011) Potential role of estradiol and progesterone in insulin resistance through constitutive androstane receptor. J Mol Endocrinol 47 229-239... 

Perhaps the most interesting questions, however, in this problem arise in relationship to the sex hormones. This is not the place to give a complete summary of the development of our knowledge of this subject. By the early 1930s the constitution of the naturally occurring estrogens had been deduced and they are five in number estriol, estrone, estradiol equilene, and equilenin. The formulae are reproduced below (b, c, d, e, f). 

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