Estimated amount interval detection

TCDD was absorbed (less than 50% of the applied dose) at each interval of measurement, about 70% of detected radioactivity on the skin could be removed by swabbing with acetone. About 15% of the dose was detected in the liver of rats 24 hours after dermal exposure to 26 ng of 2,3,7,8-TCDD in 50% methanol (Poiger and Schlatter 1980). It was estimated that the amount absorbed from the dermal exposure represents 40% of the amount absorbed from an equivalent oral dose. Absorption of... 

Variations in GH isoform detection can seriously affect the interpretation of GH stimulation tests when using different GH assays. For example, one assay may indicate an adequate amount of GH following a stimulation test, whereas another might give a low estimate of die GH concentration that could lead to misclassification of a child as GH deficient. It is important therefore that cutoff values and reference intervals be established separately for each method proposed for routine use to prevent misinterpretation and a misdiagnosis. Moreover, particular care should be taken when comparing serum GH values obtained using different immunoassay systems. 

Seven male volunteers were exposed to 2-butoxyethanol for 2 hours at the Swedish occupational exposure limit (20 ppm or 0.85 mmol/m ) during light physical exercise on a bicycle ergometer (Johanson et al. 1986a). Expired air was collected at regular time intervals for estimation of the respiratory uptake of the solvent. Capillary blood and urine were sampled, during and after the exposure period, and analyzed for 2-butoxyethanol and its metabolite, free 2-butoxyacetic acid. 2-Butoxyethanol was no longer detectable in the blood 2-4 hours after the end of exposure. The apparent values of elimination half-time, mean residence time, total blood clearance, and steady-state volume of distribution were 40 minutes, 42 minutes, 1.2 E/minute, and 54 L, respectively, for 2-butoxyethanol. The half-life for 2-butoxyethanol in urine was 1.36 hours. The amount of 2-butoxyethanol excreted in urine was less than... 

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