Esters, 4-hydroxy synthesis

Synthesis of substituted acetic acids via acetoacetic ester... 146 Synthesis of substituted acetic acid via malonic ester. .. 150 a halo acids, a hydroxy acids, and a, (3 unsaturated acids.. .153... 

Fischer indole cyclization and transformation of a nitrile to an ester (Pinner synthesis) to yield diethyl 5-hydroxy-1 T/-pyrrolo[2,3-/]quinoline-2,7-dicarboxylate (183) was performed in one step by... 

Active Esters. The synthesis of reactive esters of acylamino acids and their use in lengthening a peptide chain by reaction at the amino end is a justifiably popular method racemization is avoided, yields are good, and purification of the products is relatively easy. Esters of N-hydroxy-succinimide (l), N-hydroxypiperidine (ll) and 8-hydroxyquinoline (III) have received particular attention during I966. 

Righi G, Rumboldt G (1996) Stereoselective Preparation of Syn o -Hydroxy-/5-amino Ester Units via Regioselective Opening of a,/5-Epoxy Esters Enantioselective Synthesis of Taxol C-13 Side Chain and Cyclohexylnorstatine. J Org Chem 61 3557... 

Bonini, C., R Pucci, R. Racioppi, and L. Viggiani Enzyme Catalysed Lactonization of 3,5-Dihydroxy Esters Enantioselective Synthesis of Naturally Occurring 3-Hydroxy-5-decanolide, (-)-Massoialactone and 3-Hydroxy-5-eicosanolide. Tetrahedron Asymmetry, 3, 29 (1992). 

Shimizu, K., K. Nakayama, and M. Akiyama N-Hydroxy Amides. II. N-Benzyl-oxy-a-Amino Acid N-Hydroxysuccinimide Esters and Synthesis of a Hexapeptide Having an Alternating N-Hydroxy Amide - Amide Sequence. Bull. Chem. Soc. Japan 57, 2456 (1984). 

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