Escherichia coli MnSOD

The cytoplasm of Escherichia coli contains dimeric MnSOD, dimeric FeSOD,... 

MnSOD catalyzes the dismutation of H02 into dioxygen and hydrogen peroxide. As a redox enzyme, it shuttles between the Mn" and the Mn111 oxidation states (77). This process has been studied, and the enzyme has been shown to catalyze this reaction at a rate of 1-2.2 X 109 M s-1, which is at the diffusion limit (52). A representation of the proposed catalytic cycle is shown in Scheme 3 (78). Several studies on MnSOD kinetics have been published (78-82). Early studies on the reaction of MnSOD from Escherichia coli and Bacillus thermophilus indicated evidence for a four-step process involving two fast and... 

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