Erythromycin hydrophobic interactions

Macrocyclic antibiotics, for example, erythromycin and vancomycin, have also been used as impregnating agents for TLC resolution of enantiomers of dansyl amino acids by Bhushan and Parshad [6] and Bhushan and Thiong o [7]. Separation in this case is due to chirality of macrocyclic antibiotic molecule, which is ionizable and contains hydrophobic and hydrophilic moieties as well providing enantioseparation via n-n complexation, H-bonding, inclusion in a hydrophobic pocket, dipole stacking, steric interactions, or combination thereof. In view of the scope of the chapter and nonavailability of reports related to NSAIDs, these are not being discussed here. 

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